The Design Spot create a design solution to Dr. Macrene Skin Results - 37 Extreme Actives The brand was initially launched with just one skincare product by Park Avenue dermatologist, Dr. Macrene Alexiades-Armenakas. The design needed to communicate that this was a high performance, luxury product, that contained 37 Active Ingredients, but also that those ingredients collectively address a multitude of “skin concerns”, and that this one product “does it all” , while still presenting an upscale package design.